TR 2018 04731 T4 Received Document_Turkey 3153187 Country Stage_EPO 3153187 Received Document_Germany, France, England
The present invention relates to the production method of a biodegradable and biocompatible tissue scaffold which is designed to support cell proliferation by being implanted to the tissue during tissue regeneration after defect of a cartilage and/or bone tissue. It comprises the steps of synthesizing polypropylene fumarate (PPF) pre-polymer, mixing PPF with vinyl phosphonic acid (VPA) or vinyl phosphonic acid ester (VPES), curing the mixture by heating it in the presence of a radical initiator, then obtaining the porous or nonporous biopolymer that will be used as tissue scaffold.